Second round commenced in Astana.
Including final first round matches.
2022 Astana Open, an ATP 500 tournament, on Hard Indoor, in Astana, Kazakhstan, 3-9 October 2022.
2021 champion (not defending):
Kwon Soon-woo who defeated James Duckworth 7-6(6) 6-3
6th seed Jannik Sinner withdrew after the main draw was published due to an ankle injury, and was replaced by lucky loser Pavel Kotov.
Marin Cilic was instated as 9th seed and moved in the draw to the place previously occupied by Sinner.
Qualifier Alexander Shevchenko took the place in the draw previously occupied by Cilic.
Kotov took the place in the draw originally allocated to a qualifier, and defeated Alejandro Davidovich Fokina.
First round results:
- Marin Cilic (9) defeated Oscar Otte 5-7 7-6(4) 6-2
- Wildcard Novak Djokovic (4) defeated Cristian Garin 6-1 6-1
- Emil Ruusuvuori defeated Marc-Andrea Huesler 6-0 6-2
Second round results:
- Adrian Mannarino defeated lucky loser David Goffin 3-6 6-1 7-5
- Andrey Rublev (5) defeated qualifier Zhang Zhizhen 6-3 6-2
- Stefanos Tsitsipas (3) defeated qualifier Luca Nardi 7-6(2) 7-6(3)
- Roberto Bautista Agut defeated lucky loser Pavel Kotov 6-1 7-6(5)
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