First round commenced in Astana.
2022 Astana Open, an ATP 500 tournament, on Hard Indoor, in Astana, Kazakhstan, 3-9 October 2022.
2021 champion (not defending):
Kwon Soon-woo who defeated James Duckworth 7-6(6) 6-3
6th seed Jannik Sinner withdrew after the main draw was published due to an ankle injury, and was replaced by lucky loser Pavel Kotov.
Marin Cilic was instated as 9th seed and moved in the draw to the place previously occupied by Sinner.
Qualifier Alexander Shevchenko took the place in the draw previously occupied by Cilic.
Kotov took the place in the draw originally allocated to a qualifier, and would play Alejandro Davidovich Fokina.
Holger Rune withdrew after the main draw was published due to a knee injury, and was replaced by lucky loser David Goffin.
First round results:
- Adrian Mannarino defeated wildcard Stan Wawrinka 1-6 6-2 6-3
- Qualifier Zhang Zhizhen defeated Aslan Karatsev 4-6 6-4 6-1
- Andrey Rublev (5) defeated qualifier Laslo Djere 6-4 6-3
- Hubert Hurkacz (7) defeated Francisco Cerundolo 6-2 7-6(2)
- Botic van de Zandschulp defeated wildcard Beibit Zhukayev 6-1 6-1
- Roberto Bautista Agut defeated Felix Auger-Aliassime (8) 6-4 7-6(6)
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