First round commenced in San Jose.
2022 Mubadala Silicon Valley Classic, a WTA 250 tournament, on Hard, in San Jose, California, USA, 1-7 August 2022.
2021 champion (not defending):
Danielle Collins (7) who defeated Daria Kasatkina (4) 6-3 6-7(10) 6-1
Fifth seed Garbiñe Muguruza withdrew after the main draw was published due to injury, and was replaced by lucky loser Caroline Dolehide.
Veronika Kudermetova was instated as ninth seed and moved in the draw to the place previously occupied by Muguruza.
Qualifier Taylor Townsend took the place in the draw previously occupied by Kudermetova.
Dolehide took the place in the draw originally allocated to a qualifier, and would play qualifier Kayla Day.
First round results:
- Amanda Anisimova defeated wildcard Ashlyn Krueger 6-2 7-6(5)
- Karolina Pliskova (8) defeated wildcard Katie Boulter 1-6 7-6(5) 6-3
- Madison Keys defeated Zhang Shuai 6-4 6-2
- Daria Kasatkina (7) defeated Elena Rybakina 1-6 6-2 6-0
- Qualifier Taylor Townsend defeated qualifier Storm Sanders 6-1 6-4
- Qualifier Elizabeth Mandlik defeated Alison Riske-Amritraj 6-3 6-3
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