First round continued in Cincinnati.
2022 Western & Southern Open, an ATP Masters 1000 tournament, on Hard, in Cincinnati, Ohio, USA, 15-21 August 2022.
2021 champion (not defending):
Alexander Zverev (3) who defeated Andrey Rublev (4) 6-2 6-3
Alexander Bublik withdrew after the main draw was published due to a leg injury, and was replaced by lucky loser Fabio Fognini.
Qualifier Henri Laaksonen took the place in the draw previously occupied by Bublik.
Fognini took the place in the draw previously allocated to a qualifier, and would play Albert Ramos-Vinolas.
First round results:
- Denis Shapovalov defeated Grigor Dimitrov (16) 7-6(4) 6-3
- Aslan Karatsev defeated Brandon Nakashima 7-5 7-5
- Diego Schwartzman (13) defeated Alex Molcan 5-7 6-4 6-2
- Frances Tiafoe defeated Matteo Berrettini (12) 7-6(3) 4-6 7-6(5)
- Wildcard Sebastian Korda defeated Karen Khachanov 6-3 6-4
- John Isner defeated Benjamin Bonzi v John Isner 7-6(11) 3-6 7-6(4)
- Andy Murray defeated Stan Wawrinka 7-6(3) 5-7 7-5
- Cameron Norrie (9) defeated Holger Rune 7-6(5) 4-6 6-4
- Marin Cilic (14) defeated qualifier Jaume Munar 6-3 6-3
- Emil Ruusuvuori defeated wildcard J.J. Wolf 7-6(2) 6-2
- Roberto Bautista Agut (15) defeated Francisco Cerundolo 6-7(5) 6-4 6-2
- Qualifier Marcos Giron defeated qualifier David Goffin 6-3 6-4
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