US Open - Women’s Singles 1R start

Day One - First round commenced at the 2022 US Open.

2022 US Open, on Hard, in New York City, New York, USA, 29 August - 11 September 2022.

Defending champion:

Qualifier Emma Raducanu who defeated Leylah Fernandez 6-4 6-3

First round results:

- Qualifier Daria Snigur defeated Simone Halep (7) 6-2 0-6 6-4

- Rebecca Marino defeated Magdalena Frech 6-2 6-3

- Anna Karolina Schmiedlova defeated Nadia Podoroska 6-3 6-2

- Zhang Shuai defeated Jil Teichmann (30) 6-4 6-2

- Madison Keys (20) defeated Dayana Yastremska 7-6(3) 6-3

- Camila Giorgi defeated Anna Bondar 4-6 6-3 6-1

- Elena-Gabriela Ruse defeated Daria Saville 3-6 6-2 6-4

- CoCo Gauff (12) defeated qualifier Leolia Jeanjean 6-2 6-3

- Beatriz Haddad Maia (15) defeated Ana Konjuh 6-0 6-0

- Bianca Andreescu defeated wildcard Harmony Tan 6-0 3-6 6-1

- Anna Kalinskaya defeated Rebecca Peterson 6-4 6-3

- Caroline Garcia (17) defeated lucky loser Kamilla Rakhimova 6-2 6-4

- Alison Riske-Amritraj (29) defeated wildcard Eleana Yu 6-2 6-4

- Camila Osorio defeated Ann Li 1-6 6-3 6-1

- Wang Xiyu defeated Diane Parry 5-7 6-3 6-3

- Maria Sakkari (3) defeated Tatjana Maria 6-4 3-6 6-0

- Ons Jabeur (5) defeated Madison Brengle 7-5 6-2

- Wildcard Elizabeth Mandlik defeated Tamara Zidansek 5-7 7-6(3) 6-4

- Qualifier Viktoria Kuzmova defeated Sara Sorribes Tormo 6-3 6-4

- Shelby Rogers (31) defeated Arantxa Rus 3-6 6-3 6-4

- Veronika Kudermetova (18) defeated Donna Vekic 7-5 6-3

- Maryna Zanevska defeated wildcard CoCo Vandeweghe 6-1 7-5

- Dalma Galfi defeated Nuria Parrizas Diaz 6-4 6-3

- Harriet Dart defeated Daria Kasatkina (10) 7-6(8) 1-6 6-3

- Leylah Fernandez (14) defeated Oceane Dodin 6-3 6-4

- Liudmila Samsonova defeated qualifier Sara Bejlek 6-3 6-1

- Aleksandra Krunic defeated qualifier Elina Avanesyan 6-4 6-4

- Barbora Krejcikova (23) defeated qualifier Fernanda Contreras Gomez 6-0 6-4

- Evgeniya Rodina defeated Martina Trevisan (27) 7-5 6-1

- Ajla Tomljanovic defeated Karolina Muchova 6-3 7-6(5)

- Serena Williams defeated Danka Kovinic 6-3 6-3

- Anett Kontaveit (2) defeated Jaqueline Cristian 6-3 6-0