US Open - Men’s Singles 1R start

Day One - First round commenced at the 2022 US Open.

2022 US Open, on Hard, in New York City, New York, USA, 29 August - 11 September 2022.

Defending champion:

Daniil Medvedev (2) who defeated Novak Djokovic (1) 6-4 6-4 6-4

Hugo Dellien withdrew after the main draw was published, and was replaced by lucky loser Fernando Verdasco.

Qualifier Nicolas Jarry took the place in the draw previously occupied by Dellien.

Verdasco took the place in the draw originally allocated to a qualifier.

Pablo Andujar withdrew after the main draw was published, and was replaced by lucky loser Hugo Grenier.

First round results:

- Daniil Medvedev (1) defeated Stefan Kozlov 6-2 6-4 6-0

- Arthur Rinderknech defeated Quentin Halys 4-6 7-6(4) 6-3 6-2

- Nuno Borges defeated wildcard Ben Shelton 7-6(6) 3-6 7-6(5) 6-7(8) 6-3 

- Qualifier Wu Yibing defeated Nikoloz Basilashvili (31) 6-3 6-4 6-0

- Nick Kyrgios (23) defeated Thanasi Kokkinakis 6-3 6-4 7-6(4)

- Benjamin Bonzi defeated wildcard Ugo Humbert 7-6(1) 6-1 5-7 3-6 6-2

- Alejandro Tabilo defeated Kamil Majchrzak 6-1 6-4 6-7(3) 6-1

- Wildcard J.J. Wolf defeated Roberto Bautista Agut (16) 6-4 6-4 6-4

- Pablo Carreno Busta (12) defeated wildcard Dominic Thiem 7-5 6-1 5-7 6-3

- Alexander Bublik defeated Hugo Gaston 6-4 6-4 6-4

- Cristian Garin defeated Jiri Lehecka 3-6 7-6(3) 7-5 6-1

- Alex de Minaur (18) defeated Filip Krajinovic 7-5 6-2 6-3

- Karen Khachanov (27) defeated Denis Kudla 3-6 6-1 6-2 6-2

- Thiago Monteiro defeated Alex Molcan 6-4 4-6 6-4 6-1

- Jack Draper defeated Emil Ruusuvuori 6-4 6-3 6-3

- Felix Auger-Aliassime (6) d qualifier Alexander Ritschard 6-3 6-4 3-6 6-3

-:Qualifier Daniel Elahi Galan defeated Stefanos Tsitsipas (4) 6-0 6-1 3-6 7-5

- Jordan Thompson defeated Lorenzo Sonego 2-6 1-6 6-2 6-4 6-4

- Alejandro Davidovich Fokina defeated Yoshihito Nishioka 6-3 7-5 6-3

- Marton Fucsovics defeated Maxime Cressy (30) 6-7(4) 7-5 5-1 (retired)

- Andy Murray defeated Francisco Cerundolo (24) 7-5 6-3 6-3

- Wildcard Emilio Nava defeated John Millman 7-6(7) 4-6 7-6(4) 1-6 6-1

- Lucky loser Hugo Grenier defeated Tomas Martin Etcheverry 4-6 6-2 6-3 6-4

- Matteo Berrettini (13) defeated qualifier Nicolas Jarry 6-2 6-3 6-3

- Qualifier Brandon Holt defeated Taylor Fritz (10) 6-7(3) 7-6(1) 6-3 6-4

- Pedro Cachin defeated Aljaz Bedene 6-4 6-3 5-7 1-6 7-6(10-6)

- Lucky loser Corentin Moutet defeated Stan Wawrinka 6-4 7-6(7) (retired)

- Botic van de Zandschulp (21) defeated qualifier Tomas Machac 3-6 7-6(3) 6-1 3-6 7-5

- Tommy Paul (29) defeated Bernabe Zapata Miralles 4-6 6-3 2-6 6-0 7-5

- Sebastian Korda defeated qualifier Facundo Bagnis 5-7 7-6(3) 7-5 6-1

- Tim van Rijthoven defeated qualifier Zhang Zhizhen 3-6 6-7(4) 7-6(9) 6-1 6-4

- Casper Ruud (5) defeated Kyle Edmund 6-3 7-5 6-2