First round commenced in Cincinnati.
2022 Western & Southern Open, an ATP Masters 1000 tournament, on Hard, in Cincinnati, Ohio, USA, 15-21 August 2022.
2021 champion (not defending):
Alexander Zverev (3) who defeated Andrey Rublev (4) 6-2 6-3
Alexander Bublik withdrew after the main draw was published due to a leg injury, and was replaced by lucky loser Fabio Fognini.
Qualifier Henri Laaksonen took the place in the draw previously occupied by Bublik.
Fognini took the place in the draw previously allocated to a qualifier, and would play Albert Ramos-Vinolas.
First round results:
- Botic van de Zandschulp defeated Maxime Cressy 6-2 4-6 6-4
- Wildcard Mackenzie McDonald defeated Nikoloz Basilashvili 6-0 6-1
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