First round commenced in Palermo.
2022 Palermo Ladies Open, a WTA 250 tournament, on Clay, in Palermo, Italy, 18-24 July 2022.
2021 champion (not defending):
Danielle Collins (1) defeated qualifier Elena-Gabriela Ruse 6-4 6-2
Petra Martic withdrew after the main draw was published due to an ankle injury, and was replaced by lucky loser Jaimee Fourlis.
Martic’s place in the draw was taken by qualifier Rebeka Masarova.
Fourlis took the place in the draw originally allocated to a qualifier, and she would play second seed Yulia Putintseva.
Laura Siegemund withdrew after the main draw was published due to personal reasons, and was replaced by lucky loser Julia Grabher.
First round results:
- Zhang Shuai (3) defeated qualifier Rebeka Masarova 7-6(3) 7-6(7)
- Jasmine Paolini defeated Anna Karolina Schmiedlova 6-3 6-1
- Qualifier Leolia Jeanjean defeated Ylena In-Albon 6-2 6-4
- Sara Sorribes Tormo (4) defeated Ana Bogdan 2-6 6-4 6-2
- Irina-Camelia Begu (6) defeated qualifier Marina Bassols Ribera 6-3 4-6 6-3
- Oceane Dodin defeated qualifier Matilde Paoletti 6-4 7-5
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