ATP - Winston-Salem 2R start

First round completed and second round commenced in Winston-Salem.

2021 Winston-Salem Open - an ATP 250 tournament, on Hard, in Winston-Salem, North Carolina, USA, 21-28 August 2021.

Event not held last year due to COVID-19

2019 champion (not defending):

Hubert Hurkacz (3) who defeated Benoit Paire (1) 6-3 3-6 6-3

Corentin Moutet withdrew after the main draw was published due to elbow pain, and was replaced by lucky loser Yosuke Watanuki 

First round results:

- Gianluca Mager defeated qualifier Wu Tung-lin 7-6(5) 6-3

- Ilya Ivashka defeated Andreas Seppi 6-4 6-4

- Qualifier Lucas Pouille defeated Feliciano Lopez 6-1 6-4

- Emil Ruusuvuori defeated qualifier Denis Kudla 6-3 6-4

- Federico Coria defeated Lorenzo Musetti 6-4 4-6 6-4

- Qualifier Alexei Popyrin defeated Steve Johnson 7-5 6-4

- Lucky loser Yosuke Watanuki defeated Jaume Munar 3-6 6-3 6-0

- Jordan Thompson defeated Guido Pella 6-1 1-6 6-3

Second round results:

- Dominik Koepfer (16) defeated Marco Cecchinato 5-7 6-4 6-4

- Richard Gasquet (14) defeated Egor Gerasimov 7-6(4) 7-6(6)