Top seed Rafael Nadal withdrew after the main draw was published due to a foot injury, and was replaced by lucky loser Feliciano Lopez
Lopez receives the first round bye previously given to Nadal.
Second round results:
- Qualifier James Duckworth defeated Jannik Sinner (16) 6-3 6-4
- Nikoloz Basilashvili defeated Alex de Minaur (12) 6-1 6-1
- Hubert Hurkacz (7) received a walkover from Kei Nishikori
- Andrey Rublev (4) defeated Fabio Fognini 7-6(4) 6-3
- John Isner defeated Cristian Garin (13) 4-6 6-3 6-4
- Gaël Monfils (11) defeated John Millman 3-6 6-3 6-4
- Lucky loser Frances Tiafoe defeated Denis Shapovalov (5) 6-1 6-4
- Dusan Lajovic defeated Felix Auger-Aliassime (9) 7-5 6-4
- Karen Khachanov defeated Aslan Karatsev (15) 7-6(7) 6-4
- Diego Schwartzman (8) defeated Benoit Paire 7-5 6-1
- Roberto Bautista Agut (10) defeated qualifier Tommy Paul 6-3 6-4
- Lloyd Harris defeated lucky loser Feliciano Lopez 6-2 6-3
Round of sixteen match ups
Daniil Medvedev (1) v qualifier James Duckworth
Nikoloz Basilashvili v Hubert Hurkacz (7)
Andrey Rublev (4) v John Isner
Gaël Monfils (11) v lucky loser Frances Tiafoe
Casper Ruud (6) v Dusan Lajovic
Karen Khachanov v Stefanos Tsitsipas (3)
Diego Schwartzman (8) v Roberto Bautista Agut (10)
Reilly Opelka v Lloyd Harris
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