ATP - Winston-Salem 2R complete

Second round completed and round of sixteen set in Winston-Salem.

2021 Winston-Salem Open - an ATP 250 tournament, on Hard, in Winston-Salem, North Carolina, USA, 21-28 August 2021.

Event not held last year due to COVID-19

2019 champion (not defending):

Hubert Hurkacz (3) who defeated Benoit Paire (1) 6-3 3-6 6-3

7th seed Nikoloz Basilashvili withdrew after the main draw was published due to illness, and was replaced by lucky loser Pierre-Hugues Herbert.

Herbert receives the first round bye previously given to Basilashvili.

8th seed John Millman withdrew after the main draw was published due to a foot injury, and was replaced by lucky loser Max Purcell.

Purcell receives the first round bye previously given to Millman.

2nd seed David Goffin withdrew after the main draw was published due to a knee injury, and was replaced by lucky loser Eduardo Nava.

Second round results:

- Wildcard Pablo Carreno Busta (1) defeated Soonwoo Kwon 6-3 3-6 6-4

- Jan-Lennard Struff (9) defeated Gianluca Mager 6-2 6-2

- Ilya Ivashka defeated Marin Cilic (6) 4-6 7-5 6-4

- Wildcard Daniel Evans (3) defeated qualifier Lucas Pouille 3-6 6-4 6-1

- Benoit Paire (12) defeated Gilles Simon 6-3 6-3

- Emil Ruusuvuori defeated Alexander Bublik (5) 6-2 7-6(5)

- Lucky loser Pierre-Hugues Herbert defeated Federico Coria 6-4 6-2

- Marcos Giron defeated Federico Delbonis (10) 6-3 6-4

- Carlos Alcaraz (15) defeated qualifier Alexei Popyrin 6-7(9) 6-1 7-6(1)

- Marton Fucsovics (4) defeated lucky loser Yosuke Watanuki 7-5 6-1

- Lucky loser Max Purcell defeated Jordan Thompson 7-5 6-4

- Mikael Ymer defeated Albert Ramos-Vinolas (11) 6-3 6-1

- Frances Tiafoe (13) defeated wildcard Andy Murray 7-6(4) 6-3

- Thiago Monteiro defeated lucky loser Eduardo Nava 7-5 6-1

Round of sixteen match ups 

Wildcard Pablo Carreno Busta (1) v Dominik Koepfer (16)

Jan-Lennard Struff (9) v Ilya Ivashka 

Wildcard Daniel Evans (3) v Richard Gasquet (14)

Benoit Paire (12) v Emil Ruusuvuori 

Lucky loser Pierre-Hugues Herbert v Marcos Giron 

Carlos Alcaraz (15) v Marton Fucsovics (4)

Lucky loser Max Purcell v Mikael Ymer 

Frances Tiafoe (13) v Thiago Monteiro