Andy Murray (Great Britain) withdrew due to a thigh strain and was replaced by alternate Max Purcell (Australia)
Marton Fucsovics (Hungary) withdrew due to a shoulder injury and was replaced by alternate Luke Saville (Australia)
First round results:
- Ilya Ivashka (Belarus) defeated Gaël Monfils (10) (France) 6-4 4-6 7-5
- Mikhail Kukushkin (Kazakhstan) defeated Federico Coria (Argentina) 7-6(4) 7-5
- Marcos Giron (USA) defeated Norbert Gombos (Slovakia) 7-6(4) 3-6 6-2
- Kei Nishikori (Japan) defeated Andrey Rublev (5) (ROC) 6-3 6-4
- Alexander Zverev (4) (Germany) defeated Lu Yen-hsun (Taiwan) 6-1 6-3
- Daniel Elahi Galan (Colombia) defeated Mohamed Safwat (Egypt) 7-5 6-1
- Liam Broady (Great Britain) defeated Francisco Cerundolo (Argentina) 7-5 6-7(4) 6-2
- Hubert Hurkacz (7) (Poland) defeated alternate Luke Saville (Australia) 6-2 6-4
- Diego Schwartzman (8) (Argentina) defeated Juan Pablo Varillas (Peru) 7-5 6-4
- Tomas Machac (Czech Republic) defeated Joao Sousa (Portugal) 6-7(5) 6-4 6-4
- James Duckworth (Australia) defeated Lukas Klein (Slovakia) 5-7 6-3 7-6(4)
- Karen Khachanov (12) (ROC) defeated Yoshihito Nishioka (Japan) 3-6 6-1 6-2
- Frances Tiafoe (USA) defeated Soonwoo Kwon (Korea) 6-3 6-2
- Stefanos Tsitsipas (3) (Greece) defeated Philipp Kohlschreiber (Germany) 6-3 3-6 6-3
- Dominik Koepfer (Germany) defeated Facundo Bagnis (Argentina) 3-6 6-3 7-5
- Alternate Max Purcell (Australia) defeated Felix Auger-Aliassime (9) (Canada) 6-4 7-6(2)
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