ATP - Córdoba 1R start

First round commenced in Córdoba.

2022 Córdoba Open - an ATP 250 tournament, on Clay, in Córdoba, Argentina, 31 January - 6 February 2022.

Event held last year from 20-28 February 2021.

2021 champion (not defending):

Qualifier Juan Manuel Cerundolo who defeated Albert Ramos-Vinolas 6-0 2-6 6-2

Second seed Dominic Thiem withdrew after the main draw was published due to a finger injury, and was replaced by lucky loser Nikola Milojevic.

Milojevic received the first round bye previously given to Thiem.

Defending champion Juan Manuel Cerundolo withdrew after the main draw was published due to a leg injury, and was replaced by lucky loser Daniel Elahi Galan.

First round results:

- Jaume Munar defeated Benoit Paire (7) 6-4 7-5

- Qualifier Juan Pablo Varillas defeated Facundo Bagnis 6-4 5-7 7-6(5)

- Pedro Martinez (8) defeated Thiago Monteiro 4-6 6-4 7-6(4)

- Wildcard Juan Ignacio Londero defeated Yannick Hanfmann 6-3 6-4