ATP - Madrid 2R complete

Second round completed and round of sixteen set in Madrid.

2021 Mutua Madrid Open - an ATP Masters 1000 tournament, on Clay, in Madrid, Spain, 2-9 May 2021.

Event not held last year due to COVID-19.

2019 champion (not defending):

Novak Djokovic (1) who defeated Stefanos Tsitsipas (8) 6-3 6-4

Second round results:

- Rafael Nadal (1) defeated wildcard Carlos Alcaraz 6-1 6-2

- Qualifier Alexei Popyrin defeated Jannik Sinner (14) 7-6(5) 6-2

- Daniel Evans defeated John Millman 6-7(5) 6-2 6-3

- Alexander Zverev (5) defeated Kei Nishikori 6-3 6-2

- John Isner defeated Roberto Bautista Agut (9) 6-4 6-7(4) 7-6(6)

- Aslan Karatsev defeated Diego Schwartzman (7) 2-6 6-4 6-1

- Casper Ruud defeated lucky loser Yoshihito Nishioka 6-1 6-2

- Stefanos Tsitsipas (4) defeated Benoit Paire 6-1 6-2

- Qualifier Federico Delbonis defeated Albert Ramos-Vinolas 7-6(5) 6-3

- Cristian Garin (16) defeated Dominik Koepfer 6-3 6-4

- Daniil Medvedev (2) defeated Alejandro Davidovich Fokina 4-6 6-4 6-2

Round of sixteen match ups 

Rafael Nadal (1) v qualifier Alexei Popyrin 

Daniel Evans v Alexander Zverev (5)

Dominic Thiem (3) v Alex de Minaur 

John Isner v Andrey Rublev (6)

Aslan Karatsev v Alexander Bublik 

Casper Ruud v Stefanos Tsitsipas (4)

Matteo Berrettini (8) v qualifier Federico Delbonis 

Cristian Garín (16) v Daniil Medvedev (2)