US Open - Women’s Singles 2R start

Day Three - Second round commenced at the 2022 US Open.

Including completion of unfinished rain interrupted first round match from previous day 

2022 US Open, on Hard, in New York City, New York, USA, 29 August - 11 September 2022.

Defending champion:

Qualifier Emma Raducanu who defeated Leylah Fernandez 6-4 6-3

First round results:

- Ekaterina Alexandrova (28) defeated wildcard Peyton Stearns 6-4 4-6 7-5 after play resumed from previous day

Second round results:

- Rebecca Marino defeated qualifier Daria Snigur 6-3 7-6(5)

- Zhang Shuai defeated Anna Karolina Schmiedlova 7-5 6-1

- Madison Keys (20) defeated Camila Giorgi 6-4 5-7 7-6(10-6)

- CoCo Gauff (12) defeated Elena-Gabriela Ruse 6-2 7-6(4)

- Bianca Andreescu defeated Beatriz Haddad Maia (15) 6-2 6-4

- Caroline Garcia (17) defeated Anna Kalinskaya 6-3 6-1

- Alison Riske-Amritraj (29) defeated Camila Osorio 6-4 6-7(5) 7-6(10-5)

- Wang Xiyu defeated Maria Sakkari (3) 3-6 7-5 7-5

- Ons Jabeur (5) defeated wildcard Elizabeth Mandlik 7-5 6-2

- Shelby Rogers (31) defeated qualifier Viktoria Kuzmova 7-5 6-1

- Veronika Kudermetova (18) defeated Maryna Zanevska 6-2 6-3

- Dalma Galfi defeated Harriet Dart 6-4 6-0

- Liudmila Samsonova defeated Leylah Fernandez (14) 6-3 7-6(3)

- Aleksandra Krunic defeated Barbora Krejcikova (23) 2-6 6-4 6-2

- Ajla Tomljanovic defeated Evgeniya Rodina 1-6 6-2 7-5

- Serena Williams defeated Anett Kontaveit (2) 7-6(4) 2-6 6-2