First round continued in Strasbourg.
2022 Internationaux de Strasbourg, a WTA 250 tournament, on Clay, in Strasbourg, France, 15-21 May 2022.
2021 champion (not defending):
Barbora Krejcikova (5) who defeated Sorana Cirstea 6-3 6-3
Seventh seed Tereza Martincova withdrew after the main draw was published due to a knee injury, and was replaced by lucky loser Yana Morderger.
Viktorija Golubic was instated as ninth seed and moved in the draw to the place previously occupied by Martincova.
Caroline Garcia withdrew after the main draw was published due to a foot injury, and was replaced by lucky loser Angelina Gabueva.
Elsa Jacquemot withdrew after the main draw was published due to a thigh injury, and was replaced by lucky loser Katharina Hobgarski.
First round results:
- Wildcard Karolina Pliskova (1) defeated Marta Kostyuk 6-4 6-2
- Maryna Zanevska defeated Zhang Shuai (5) 6-2 6-3
- Elise Mertens (4) defeated wildcard Carole Monnet 7-5 6-4
- Kaja Juvan defeated qualifier Lina Glushko 6-3 6-1
- Lucky loser Nefisa Berberovic defeated Sloane Stephens (6) 2-6 6-4 6-1
- Viktorija Golubic (9) defeated lucky loser Yana Morderger 6-0 6-4
- Oceane Dodin defeated Ana Konjuh 6-2 1-6 7-5
- Heather Watson defeated lucky loser Katharina Hobgarski 6-4 6-1
- Qualifier Aliaksandra Sasnovich defeated qualifier Julie Gervais 6-4 6-2
- Wildcard Angelique Kerber (2) defeated Diane Parry 6-3 6-4
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