ATP - Lyon 1R continued

First round continued in Lyon.

2022 Open Parc Auvergne-Rhône-Alpes Lyon, an ATP 250 tournament, on Clay, in Lyon, France, 15-21 May 2022.

2021 champion (not defending):

Wildcard Stefanos Tsitsipas (2) who defeated Cameron Norrie 6-3 6-3

Benjamin Bonzi withdrew after the main draw was published due to an adductor injury, and was replaced by lucky loser Yosuke Watanuki.

First round results:

- Oscar Otte defeated wildcard Lucas Pouille 6-3 6-1

- Sebastian Baez (7) defeated qualifier Tomas Martin Etcheverry 6-2 6-1

- Lucky loser Yosuke Watanuki defeated Pedro Martinez (8) 6-7(2) 6-4 6-2

- Soonwoo Kwon defeated Aljaz Bedene 4-6 7-6(4) 6-0

- Ugo Humbert defeated qualifier Gregoire Barrere 6-3 6-4

- Karen Khachanov (5) defeated qualifier Gilles Simon 6-1 6-4

- Alex Molcan defeated wildcard Jo-Wilfried Tsonga 6-4 6-4