First round commenced in Charleston.
2022 Credit One Charleston Open - a WTA 500 tournament, on Green Clay, in Charleston, South Carolina, USA, 2-10 April 2022.
2021 champion (not defending):
Veronika Kudermetova (15) who defeated Danka Kovinic 6-4 6-2
First round results:
- Amanda Anisimova (15) defeated qualifier Sachia Vickery 6-0 7-5
- Jasmine Paolini defeated qualifier Gabriela Lee 6-2 6-3
- Irina-Camelia Begu defeated Wang Xinyu 7-6(2) 6-4
- Alizé Cornet (12) defeated Alycia Parks 6-0 7-5
- Anhelina Kalinina defeated Aliaksandra Sasnovich 6-4 6-4
- Kaia Kanepi defeated Shelby Rogers 6-7(2) 7-5 6-2
- Magdalena Frech defeated Petra Kvitova (11) 7-6(6) 3-2 (retired)
- Ekaterina Alexandrova defeated qualifier Allie Kiick 6-1 6-1
- Katarina Zavatska defeated Yuan Yue 6-4 6-2
- Qualifier Ulrikke Eikeri defeated qualifier Nadiia Kichenok 5-7 6-2 6-2
- Wildcard Linda Fruhvirtova defeated Ana Konjuh 4-6 6-1 6-3
- Zhang Shuai (16) defeated qualifier Francesca Di Lorenzo 6-2 6-4
- Claire Liu defeated lucky loser Heather Watson 6-4 6-2
- Anna Bondar defeated Arianne Hartono 6-1 6-4
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