WTA - Madrid 2R start

Second round commenced in Madrid.

2025 Mutua Madrid Open, a WTA 1000 tournament, on Clay Outdoor, Madrid, Spain, 22 April - 4 May 2025.

Defending champion:

Iga Swiatek (1) who defeated Aryna Sabalenka (2) 7-5 4-6 7-6(7)

12th seed Karolína Muchová withdrew after the main draw was published due to illness, and was replaced by lucky loser Elisabetta Cocciaretto.

Cocciaretto received the first round bye originally given to Muchová.

Second round results:

- Mirra Andreeva (7) defeated Marie Bouzková 6-3 6-4

- Magdalena Fręch (27) defeated Jéssica Bouzas Maneiro 5-7 7-6(2) 6-4

- Liudmila Samsonova (18) defeated Caroline Dolehide 6-4 6-4

- Qualifier Yuliia Starodubtseva defeated lucky loser Elisabetta Cocciaretto 7-6(5) 6-4

- Beatriz Haddad Maia (16) defeated lucky loser Bernarda Pera 2-6 6-3 6-1

- Belinda Bencic defeated Clara Tauson (20) 7-5 7-5

- Ann Li defeated Leylah Fernandez (25) 6-4 3-6 6-4

- CoCo Gauff (4) defeated Dayana Yastremska 0-6 6-2 7-5

- Madison Keys (5) defeated Lucia Bronzetti 6-4 6-3

- Anna Kalinskaya (30) defeated qualifier Diane Parry 7-6(4) 6-4

- Donna Vekić (19) defeated wildcard Hailey Baptiste 6-4 6-3

- Emma Navarro (11) defeated qualifier Maya Joint 7-5 7-5

- Diana Shnaider (13) defeated Katie Volynets 6-1 6-2

- Anastasija Sevastova defeated Jeļena Ostapenko (23) 7-6(2) 6-2

- Linda Nosková (31) defeated qualifier María Lourdes Carlé 7-5 6-1

- Iga Swiatek (2) defeated wildcard Alexandra Eala 4-6 6-4 6-2