ATP - Madrid 2R complete

Second round completed in Madrid.

2025 Mutua Madrid Open, an ATP Masters 1000 tournament, on Clay Outdoor, Madrid, Spain, 22 April - 4 May 2025.

Defending champion:

Andrey Rublev (7) who defeated Felix Aliassime 4-6 7-5 7-5

Second seed Carlos Alcaraz withdrew after the main draw was published due to a muscle strain, and was replaced by lucky loser Kamil Majchrzak.

Majchrzak received the first round bye originally given to Alcaraz.

Second round results:

- Jack Draper (5) defeated Tallon Griekspoor 6-3 6-4

- Matteo Berrettini (30) defeated Marcos Giron 6-7(3) 7-6(6) 6-1

- Karen Khachanov (24) defeated Reilly Opelka 7-6(3) 7-6(4)

- Tommy Paul (11) defeated Joao Fonseca 7-6(7) 7-6(3)

- Frances Tiafoe (16) defeated Luciano Darderi 7-5 3-1 (retired)

- Alexandre Müller defeated Ugo Humbert (21) 6-2 6-7(3) 7-6(5)

- Damir Džumhur defeated Sebastián Báez (32) 1-6 6-1 6-2

- Matteo Arnaldi defeated Novak Djokovic (4) 6-3 6-4

- Alex de Minaur (6) defeated Lorenzo Sonego 6-2 6-3

- Denis Shapovalov (29) defeated Kei Nishikori 6-1 6-4

- Stefanos Tsitsipas (17) defeated Jan-Lennard Struff 3-6 6-4 6-3

- Lorenzo Musetti (10) defeated Tomás Martín Etcheverry 7-6(3) 6-2

- Grigor Dimitrov (15) defeated Nicolás Jarry 6-3 6-4

- Qualifier Jacob Fearnley defeated Tomáš Macháč (19) 1-6 6-3 6-2

- Cameron Norrie defeated Jiří Lehečka (26) 2-6 6-4 6-0

- Lucky loser Gabriel Diallo defeated lucky loser Kamil Majchrzak 7-5 4-6 6-4