ATP - Madrid 1R start

First round commenced in Madrid.

2025 Mutua Madrid Open, an ATP Masters 1000 tournament, on Clay Outdoor, Madrid, Spain, 22 April - 4 May 2025.

Defending champion:

Andrey Rublev (7) who defeated Felix Aliassime 4-6 7-5 7-5

Second seed Carlos Alcaraz withdrew after the main draw was published due to a muscle strain, and was replaced by lucky loser Kamil Majchrzak.

Majchrzak received the first round bye originally given to Alcaraz.

Roberto Carballes Baena withdrew after the main draw was published due to a hip injury, and was replaced by lucky loser Rinky Hijikata.

Jordan Thompson withdrew after the main draw was published due to back pain, and was replaced by lucky loser Botic van de Zandschulp.

Yoshihito Nishioka withdrew after the main draw was published due to a shoulder injury, and was replaced by lucky loser Gabriel Diallo.

First round results:

- Roberto Bautista Agut defeated Jaume Munar 6-4 2-6 6-3

- Nuno Borges defeated wildcard Pablo Carreño Busta 6-7(7) 7-6(3) 6-3

- Qualifier Harold Mayot defeated Corentin Moutet 6-3 4-2 (retired)

- Francisco Comesaña defeated Pedro Martinez 6-4 6-4

- Mariano Navone defeated Giovanni Mpetshi Perricard 6-4 6-4

- Qualifier Ethan Quinn defeated qualifier Dusan Lajović 6-3 6-4

- Alexander Bublik defeated Alex Michelsen 7-6(2) 7-6(4)

- Gaël Monfils defeated qualifier Borna Gojo 1-6 6-2 6-4

- Christopher O’Connell defeated Camilo Ugo Carabelli 6-3 6-4

- Benjamin Bonzi defeated wildcard Marin Čilić 6-3 6-2

- Wildcard Federico Cinà defeated wildcard Coleman Wong 7-6(5) 6-1

- Arthur Rinderknech defeated Roman Safiullin 7-6(4) 6-1

- Laslo Djere defeated qualifier Fabio Fognini 6-2 6-3

- Qualifier Juan Manuel Cerúndolo defeated Aleksandar Kovacevic 3-6 7-5 6-2

- Sebastian Ofner defeated qualifier Hugo Gaston 6-4 6-3

- Flavio Cobolli defeated Fabian Marozsán 7-6(4) 7-5