ATP - Madrid 2R start

Second round commenced in Madrid.

2025 Mutua Madrid Open, an ATP Masters 1000 tournament, on Clay Outdoor, Madrid, Spain, 22 April - 4 May 2025.

Defending champion:

Andrey Rublev (7) who defeated Felix Aliassime 4-6 7-5 7-5

Second seed Carlos Alcaraz withdrew after the main draw was published due to a muscle strain, and was replaced by lucky loser Kamil Majchrzak.

Majchrzak received the first round bye originally given to Alcaraz.

Second round results:

- Alexander Zverev (1) defeated Roberto Bautista Agut 6-2 6-2

- Alejandro Davidovich Fokina (28) defeated Nuno Borges 6-2 6-3

- Francisco Cerúndolo (20) defeated qualifier Harold Mayot 6-3 6-4

- Francisco Comesaña defeated Arthur Fils (13) 7-6(4) 6-4

- Ben Shelton (12) defeated Mariano Navone 4-6 7-6(5) 6-3

- Jakub Menšík (22) defeated qualifier Ethan Quinn 7-6(4) 6-1

- Alexander Bublik defeated Alexei Popyrin (25) 6-4 7-6(4)

- Andrey Rublev (7) received a walkover from Gaël Monfils 

- Taylor Fritz (3) defeated Christopher O’Connell 6-1 6-4

- Benjamin Bonzi defeated Hubert Hurkacz (27) 6-4 7-5

- Sebastian Korda (23) defeated wildcard Federico Cinà 6-3 3-6 6-1

- Casper Ruud (14) defeated Arthur Rinderknech 6-3 6-4

- Daniil Medvedev (9) received a walkover from Laslo Djere 

- Qualifier Juan Manuel Cerúndolo defeated Félix Auger-Aliassime (16) 7-6(5) 6-4

- Brandon Nakashima (31) defeated Sebastian Ofner 6-3 7-6(3)

- Flavio Cobolli defeated Holger Rune (8) 6-2 (retired)