WTA - Madrid 1R start

First round commenced in Madrid.

2025 Mutua Madrid Open, a WTA 1000 tournament, on Clay Outdoor, Madrid, Spain, 22 April - 4 May 2025.

Defending champion:

Iga Swiatek (1) who defeated Aryna Sabalenka (2) 7-5 4-6 7-6(7)

Anhelina Kalinina withdrew after the main draw was published due to illness, and was replaced by lucky loser Bernarda Pera.

12th seed Karolína Muchová withdrew after the main draw was published due to illness, and was replaced by lucky loser Elisabetta Cocciaretto.

Cocciaretto received the first round bye originally given to Muchová.

9th seed Paula Badosa withdrew after the main draw was published due to a back injury, and was replaced by lucky loser Cristina Bucşa.

Bucşa received the first round bye originally given to Badosa.

First round results:

- Camila Osorio defeated wildcard Emiliana Arango 6-3 6-3

- Peyton Stearns defeated Kimberly Birrell 5-7 6-3 6-4

- Lulu Sun defeated Varvara Gracheva 3-6 6-1 6-4

- Katie Boulter defeated Kateřina Siniaková 4-6 6-2 6-1

- Marie Bouzková defeated Renata Zarazúa 6-2 4-6 6-1

- Jéssica Bouzas Maneiro defeated Mayar Sherif 6-3 6-1

- Caroline Dolehide defeated Elina Avanesyan 6-4 6-4

- Lucia Bronzetti defeated Naomi Osaka 6-4 2-6 6-4

- Wildcard Hailey Baptiste defeated Sorana Cîrstea 6-2 5-7 7-6(4)

- Alexandra Eala defeated Viktoriya Tomova 6-3 6-2