Miami Open - ATP 2R start

Second round commenced in Miami Open - ATP Masters 1000

2021 Miami Open - an ATP Masters 1000 tournament, on Hard Outdoor, in Miami, Florida, USA, 22 March - 4 April 2021.

Event not held last year due to COVID-19.

2019 champion (not defending):

Roger Federer (4) who defeated John Isner (7) 6-1 6-4

Second round results:

- Daniil Medvedev (1) defeated Lu Yen-Hsun 6-2 6-2

- Alexei Popyrin defeated Reilly Opelka (30) 6-4 6-2

- Frances Tiafoe defeated Daniel Evans (19) 6-7(5) 6-3 6-3

- Dusan Lajovic (16) defeated qualifier Ernesto Escobedo 6-2 6-3

- Felix Auger-Aliassime (11) defeated Pierre-Hugues Herbert 6-4 6-4

- John Isner (18) defeated qualifier Mackenzie McDonald 2-6 6-3 7-5

- Jan-Lennard Struff (31) defeated Ricardas Berankis 6-3 6-4

- Roberto Bautista Agut (7) received a walkover from Lloyd Harris due to a wrist injury

- Emil Ruusuvuori defeated Alexander Zverev (3) 1-6 6-3 6-1

- Mikael Ymer defeated Nikoloz Basilashvili (27) 6-3 4-6 6-4

- Jannik Sinner (21) defeated wildcard Hugo Gaston 6-2 6-2

- Karen Khachanov (14) defeated Yannick Hanfmann 6-3 6-2

- Cameron Norrie defeated Grigor Dimitrov (9) 7-5 7-5

- Taylor Fritz (22) defeated Marcos Giron 6-2 6-2

- Alexander Bublik (32) defeated Laslo Djere 6-3 6-4

- James Duckworth defeated David Goffin (8) 6-3 6-1