Miami Open - ATP 1R start

First round commenced in Miami Open - ATP Masters 1000

2021 Miami Open - an ATP Masters 1000 tournament, on Hard Outdoor, in Miami, Florida, USA, 22 March - 4 April 2021.

Event not held last year due to COVID-19.

2019 champion (not defending):

Roger Federer (4) who defeated John Isner (7) 6-1 6-4

Andy Murray withdrew after the main draw was published due to a groin injury, and was replaced by lucky loser Federico Gaio.

First round results:

- Lu Yen-Hsun defeated Sam Querrey 6-3 6-4

- Alexei Popyrin defeated Feliciano López 6-4 7-6(4)

- Frances Tiafoe defeated Stefano Travaglia 5-7 6-4 6-2

- Qualifier Ernesto Escobedo defeated qualifier Paolo Lorenzi 6-3 6-2

- Pierre-Hugues Herbert defeated Pedro Sousa 6-1 6-3

- Qualifier Mackenzie McDonald defeated Vasek Pospisil 6-3 4-6 6-3

- Ricardas Berankis defeated lucky loser Federico Gaio 7-6(4) 6-2

- Lloyd Harris defeated qualifier Emilio Nava 6-4 7-6(7)

- Emil Ruusuvuori defeated wildcard Carlos Alcaraz 6-4 2-6 7-5

- Mikael Ymer defeated qualifier Alejandro Tabilo 6-3 6-1

- Wildcard Hugo Gaston defeated Dominik Koepfer 6-1 6-4

- Yannick Hanfmann defeated Steve Johnson 7-5 6-2

- Cameron Norrie defeated Yoshihito Nishioka 6-1 3-6 7-5

- Marcus Giron defeated Tommy Paul 7-6(5) 6-4

- Laslo Djere defeated Jiri Vesely 6-3 5-7 6-1

- James Duckworth defeated qualifier Mischa Zverev 6-2 4-6 6-4